Cryo-Electron Microscopy and Tomography
The Past, the Present and the Future
Prof. Dr. Jürgen Plitzko
Max Planck Institute for Biochemistry, Martinsried, Germany
What? Physics Colloquium
Where? Lecture Hall P2, Petersgasse 16, Technische Universität Graz
When? Tuesday, 23 January 17:15, 16:50 meet the speaker tea
However, proteins have their biological function in the complex environment of the cell and interact with other macromolecules. The exciting potention of cryo-EM therfore lies in cryo-electron tomography, the three-dimensional analysis of biological structures in the undisturbed cellular context (i.e. in situ). This method closes the gap between molecular and cytological structural research. After a brieef look back, this lecture will present our recent work in the field of cryo-electron tomography and in situ structural biology and highlights technological developments, limitations and their opportunities. Furthermore, it will give a prospective towards obtaining structural insights from an in situ context, possibly at atomic resolution.
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Cryo Transmission Electron Microscopy